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The results indicated that the expression levels of Bcl2 and Bcl2l1 were significantly decreased in the hypo group, while the expression level of Bad was remarkably increased

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The SELECT trial, which evaluated semaglutide 2.4 mg against placebo for cardiovascular outcomes in patients with overweight and obesity without type 2 diabetes, showed significant decreases in total cholesterol, LDL-C, and triglycerides and an increase in HDL-C at 39.8 months [48]